CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Wenhai Road 1, Qingdao 266237, China.
Mar Drugs. 2022 Aug 18;20(8):529. doi: 10.3390/md20080529.
Five new aromatic polyketides, including a unique benzofuran derivative, talarominine A (), and four chromone analogs talamins A-D (-), along with one known related metabolite, 5-hydroxy-7-methoxy-2,3-dimethylchromone (), were isolated and identified from the CS-138, an endozoic fungus obtained from the deep-sea cold seep mussel . Their chemical structures were elucidated by detailed analysis of their NMR spectra, HRESIMS and X-ray crystallographic data, and by comparison with literature data as well. The antibacterial and DPPH scavenging activities of compounds - were evaluated. Compounds - showed inhibitory activity against some of the tested bacteria whereas compounds and showed potent DPPH radical scavenging activities, which were better than that of the positive control butylated hydroxytoluene (BHT). This work is likely the first report on marine natural products of mussel-derived fungus living in cold seep environments.
从深海冷泉贻贝内生真菌 CS-138 中分离得到了 5 个新的芳香族聚酮类化合物，包括一个独特的苯并呋喃衍生物塔劳明 A（）和 4 个色酮类似物塔拉明 A-D（-），以及一个已知的相关代谢产物 5-羟基-7-甲氧基-2,3-二甲基色酮（）。通过对它们的 NMR 光谱、HRESIMS 和 X 射线晶体学数据的详细分析，并与文献数据进行比较，确定了它们的化学结构。测试了化合物 - 的抗菌和 DPPH 清除活性。化合物 - 对一些测试的细菌表现出抑制活性，而化合物 和 表现出很强的 DPPH 自由基清除活性，优于阳性对照物丁基羟基甲苯（BHT）。这可能是首次报道生活在冷泉环境中的贻贝内生真菌的海洋天然产物。
