Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.
College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Molecules. 2022 Aug 22;27(16):5335. doi: 10.3390/molecules27165335.
Tuberculosis (TB) caused by the bacterial pathogen () remains a threat to mankind, with over a billion of deaths in the last two centuries. Recent advancements in science have contributed to an understanding of pathogenesis and developed effective control tools, including effective drugs to control the global pandemic. However, the emergence of drug resistant strains has seriously affected the TB eradication program around the world. There is, therefore, an urgent need to develop new drugs for TB treatment, which has grown researchers' interest in small molecule-based drug designing and development. The small molecules-based treatments hold significant potential to overcome drug resistance and even provide opportunities for multimodal therapy. In this context, various natural and synthetic flavonoids were reported for the effective treatment of TB. In this review, we have summarized the recent advancement in the understanding of pathogenesis and the importance of both natural and synthetic flavonoids against infection studied using in vitro and in silico methods. We have also included flavonoids that are able to inhibit the growth of non-tubercular mycobacterial organisms. Hence, understanding the therapeutic properties of flavonoids can be useful for the future treatment of TB.
结核分枝杆菌（ ）引起的结核病仍然是人类的威胁，在过去的两个世纪里，已有超过 10 亿人因此而死亡。最近科学的进步有助于我们了解发病机制并开发出有效的控制工具，包括控制全球大流行的有效药物。然而，耐药菌株的出现严重影响了全球的结核病根除计划。因此，迫切需要开发治疗结核病的新药，这引起了研究人员对基于小分子的药物设计和开发的兴趣。基于小分子的治疗方法具有克服耐药性的巨大潜力，甚至为多模式治疗提供了机会。在这种情况下，各种天然和合成类黄酮被报道可有效治疗结核病。在这篇综述中，我们总结了最近对发病机制的理解的进展，以及使用体外和计算方法研究的天然和合成类黄酮对 感染的重要性。我们还包括了能够抑制非结核分枝杆菌生长的类黄酮。因此，了解类黄酮的治疗特性可能对结核病的未来治疗有用。
