来自丝状真菌Lachnum sp. BCC 2424的色酮衍生物。

Chromone derivatives from the filamentous fungus Lachnum sp. BCC 2424.

作者信息

Rukachaisirikul Vatcharin, Chantaruk Sirinya, Pongcharoen Wipapan, Isaka Masahiko, Lapanun Sanisa

机构信息

Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand.

出版信息

J Nat Prod. 2006 Jun;69(6):980-2. doi: 10.1021/np060164e.

DOI:10.1021/np060164e

PMID:16792425

Abstract

Five new chromones, named lachnones A-E (1-5), were isolated from the filamentous fungus Lachnum sp. BCC 2424 along with known (2E,6S)-2,6-dimethyl-2,7-octadiene-1,6-diol. Their structures were elucidated by spectroscopic methods. Lachnones B (2) and D (4) mildly inhibited the growth of Mycobacterium tuberculosis, both with MIC values of 200 microg/mL.

摘要

从丝状真菌Lachnum sp. BCC 2424中分离出了五种新的色酮，命名为lachnones A-E（1-5），同时还分离出了已知的(2E,6S)-2,6-二甲基-2,7-辛二烯-1,6-二醇。通过光谱方法阐明了它们的结构。Lachnones B（2）和D（4）对结核分枝杆菌的生长有轻度抑制作用，最低抑菌浓度（MIC）值均为200μg/mL。