Lundberg Marie, Leivo Ilmo, Saarilahti Kauko, Mäkitie Antti A, Mattila Petri S
Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Central Hospital, University of Helsinki, Finland.
Acta Otolaryngol. 2011 Sep;131(9):1008-11. doi: 10.3109/00016489.2011.575796. Epub 2011 May 4.
The incidence of oropharyngeal squamous cell cancer (OPSCC) in Finland has increased during the past decades. A similar change has been seen in the relative frequency of p16-positive head and neck squamous cell carcinoma (HNSCC). As p16 is a surrogate marker for human papilloma virus (HPV) infection, and as most p16-positive HNSCCs are OPSCC, HPV infection may have had a role in the observed increased incidence of OPSCC.
Numerous studies have shown that HPV is an independent risk factor for OPSCC. We aimed to use p16 as a surrogate marker of HPV infection to study its role as a possible risk factor in OPSCC. Furthermore, the change in the incidence of OPSCC in Finland was studied.
HPV status was determined by p16 immunohistochemistry of 135 HNSCC tumour specimens retrieved from patients treated at the Helsinki University Central Hospital. Incidence data on OPSCC were obtained from the Finnish Cancer Registry.
The incidence of OPSCC in Finland increased from 0.66/100 000 person-years during 1989-1993 to 1.36 during 2004-2008. During the same period a significant increase in the relative frequency of p16 positive HNSCC tumours from 22% during 1990-1999 to 41% during 2000-2007 could be seen at our institution. In all, 85% of the p16-positive specimens were OPSCC.
在过去几十年中，芬兰口咽鳞状细胞癌（OPSCC）的发病率有所上升。在p16阳性头颈部鳞状细胞癌（HNSCC）的相对频率方面也出现了类似变化。由于p16是人乳头瘤病毒（HPV）感染的替代标志物，且大多数p16阳性HNSCC为OPSCC，HPV感染可能在观察到的OPSCC发病率增加中起到了作用。
众多研究表明HPV是OPSCC的独立危险因素。我们旨在使用p16作为HPV感染的替代标志物，研究其作为OPSCC可能危险因素的作用。此外，还研究了芬兰OPSCC发病率的变化。
通过对从赫尔辛基大学中心医院接受治疗的患者中获取的135份HNSCC肿瘤标本进行p16免疫组织化学检测来确定HPV状态。OPSCC的发病率数据来自芬兰癌症登记处。
芬兰OPSCC的发病率从1989 - 1993年期间的0.66/100 000人年增加到2004 - 2008年期间的1.36。在同一时期，在我们机构可以看到p16阳性HNSCC肿瘤的相对频率从1990 - 1999年期间的22%显著增加到2000 - 2007年期间的41%。总体而言，85%的p16阳性标本为OPSCC。
