Center for Joint Preservation and Replacement, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA.
Expert Rev Med Devices. 2011 May;8(3):339-56. doi: 10.1586/erd.11.13.
Focal lesions of the articular cartilage of the knee can be managed with a variety of products and technologies in an attempt to restore function to the afflicted joint and forestall the need for possible total knee arthroplasty. Among these approaches are non-implant-based procedures (arthroscopic chondroplasty and microfracture), grafting procedures (autografts/mosaicplasty and allografts), cell-based procedures (autologous chondrocyte implantation) and nonbiologic implants (metallic plugs and cell-free polymers). For each clinically established procedure there are also a number of investigational variations that aim to improve the in vivo quality of the regenerated/restored cartilage surface. This article analyzes existing and developing non-implant- and graft-based technologies for the repair or restoration of the articular cartilage of the knee based on a review of the published literature.
膝关节关节软骨的局灶性病变可以通过多种产品和技术来治疗，以试图恢复受累关节的功能，并防止可能需要进行全膝关节置换术。这些方法包括非植入物方法（关节镜下软骨成形术和微骨折术）、移植物方法（自体移植物/马赛克plasty 和同种异体移植物）、基于细胞的方法（自体软骨细胞移植）和非生物植入物（金属塞和无细胞聚合物）。对于每一种临床确立的方法，也有许多研究性的变化旨在改善再生/修复的软骨表面的体内质量。本文基于对已发表文献的回顾，分析了现有的和正在开发的非植入物和移植物技术，用于修复或恢复膝关节的关节软骨。
