趋化素/ChemR23 通路：超越趋化因子的系统。
Chemerin/ChemR23 pathway: a system beyond chemokines.
出版信息
Arthritis Res Ther. 2011 Apr 6;13(2):104. doi: 10.1186/ar3273.
Abstract
Chemerin is a chemokine that, through the engagement of its counter-receptor, ChemR23, attracts pro-inflammatory cells. However, chemerin has been shown to play other functions and a recent study by Berg and colleagues demonstrates that chemerin/ChemR23 is a system beyond chemokines. Human articular chondrocytes produce chemerin and express ChemR23, and upon stimulation with recombinant chemerin increase the production of pro-catabolic cytokines and metalloproteinases. The latter are up-regulated in osteoarthritic cartilage and cause extracellular matrix breakdown. Since an increase of chemerin in fat tissue and serum of obese patients has been reported, this new feature of chemerin may represent a functional link between obesity and osteoarthritis.
摘要
趋化素是一种趋化因子，通过与其受体 ChemR23 的结合，吸引促炎细胞。然而，趋化素已被证明具有其他功能，Berg 及其同事的最近一项研究表明，趋化素/ChemR23 是一个超越趋化因子的系统。人关节软骨细胞产生趋化素并表达 ChemR23，在受到重组趋化素刺激后，增加前分解代谢细胞因子和金属蛋白酶的产生。后者在骨关节炎软骨中上调，并导致细胞外基质降解。由于已经报道了肥胖患者脂肪组织和血清中趋化素的增加，因此趋化素的这一新特性可能代表肥胖症和骨关节炎之间的功能联系。
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