基因对小鼠脑刺激产生的镇痛作用的影响：II. 与脑阿片受体浓度的相关性。

Genetic influences on brain stimulation-produced analgesia in mice: II. Correlation with brain opiate receptor concentration.

作者信息

Marek P, Yirmiya R, Liebeskind J C

机构信息

Department of Behavioral Physiology, Polish Academy of Sciences, Mrokow.

出版信息

Brain Res. 1990 Jan 15;507(1):155-7. doi: 10.1016/0006-8993(90)90536-k.

DOI:10.1016/0006-8993(90)90536-k

PMID:2154297

Abstract

The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in 4 strains of mice: C57BL/6By (C57), BALB/cBy (BALB), CXBH, and CXBK. These strains are known to have high (CXBH), low (CXBK), and intermediate (C57 and BALB) concentrations of brain opiate receptors. The current intensity required for stimulation-produced analgesia (SPA) did not differ among strains. Naloxone attenuated SPA in CXBH, C57 and BALB mice, but was ineffective in the opiate receptor deficient CXBK mice. The results suggest that genetic differences in opiate receptor density can influence the degree to which opioid mechanisms are involved in SPA from the PAG.

摘要

在4种品系的小鼠中研究了电刺激中脑导水管周围灰质（PAG）的镇痛效果：C57BL/6By（C57）、BALB/cBy（BALB）、CXBH和CXBK。已知这些品系的脑阿片受体浓度分别为高（CXBH）、低（CXBK）和中等（C57和BALB）。刺激产生镇痛（SPA）所需的电流强度在各品系之间没有差异。纳洛酮减弱了CXBH、C57和BALB小鼠的SPA，但对阿片受体缺陷的CXBK小鼠无效。结果表明，阿片受体密度的遗传差异可影响阿片类机制参与PAG产生的SPA的程度。