阿司匹林与家族性腺瘤性息肉病：兜兜转转。
Aspirin and familial adenomatous polyposis: coming full circle.
机构信息
Massachusetts General Hospital, Department of Medicine, Gastrointestinal Unit, Boston, MA 02114, USA.
出版信息
Cancer Prev Res (Phila). 2011 May;4(5):623-7. doi: 10.1158/1940-6207.CAPR-11-0157.
Abstract
This perspective discusses the clinical trial reported by Burn and colleagues in this issue of the journal (beginning on page 655), which assessed aspirin and resistant starch for the prevention of colorectal adenomas in patients with familial adenomatous polyposis (FAP). The findings are examined in the context of previous clinical trials of aspirin in patients with sporadic adenomas and of sulindac or celecoxib in patients with FAP. This newly reported work raises important considerations of a role for aspirin in the clinical management of FAP patients and adds to considerations of a role for aspirin in the chemoprevention of colorectal cancer among broader populations.
摘要
这篇观点文章讨论了 Burn 及其同事在本期杂志（第 655 页开始）上报告的临床试验，该试验评估了阿司匹林和抗性淀粉在预防家族性腺瘤性息肉病（FAP）患者结直肠腺瘤中的作用。该研究结果在阿司匹林治疗散发性腺瘤患者的先前临床试验以及舒林酸或塞来昔布治疗 FAP 患者的临床试验背景下进行了检查。这项新报告的工作提出了阿司匹林在 FAP 患者临床管理中的作用的重要考虑因素，并增加了阿司匹林在更广泛人群结直肠癌化学预防中的作用的考虑因素。
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