Kataoka Takahiro, Sakoda Akihiro, Yoshimoto Masaaki, Nakagawa Shinya, Toyota Teruaki, Nishiyama Yuichi, Yamato Keiko, Ishimori Yuu, Kawabe Atsushi, Hanamoto Katsumi, Taguchi Takehito, Yamaoka Kiyonori
Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan.
Radiat Prot Dosimetry. 2011 Jul;146(1-3):360-3. doi: 10.1093/rpd/ncr189. Epub 2011 May 3.
Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl(4)) administration. Results showed that radon inhalation alleviates CCl(4)-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.
我们之前的研究表明，抗氧化功能的激活有可能减轻与生活方式疾病相关的各种氧化损伤。结果显示，低剂量X射线照射可激活超氧化物歧化酶，并抑制缺血再灌注后的水肿。为了减轻移植中的缺血再灌注损伤，研究了在肝脏切除后立即使用低剂量X射线照射对肝移植中抗氧化功能的影响。结果表明，肝移植因照射而激活了抗氧化功能。此外，吸入氡可增强某些器官的抗氧化功能，并减轻酒精诱导的小鼠肝脏氧化损伤。此外，为了确定吸入氡的最有效条件，小鼠在给予四氯化碳（CCl₄）之前或之后吸入氡。结果显示，吸入氡可减轻CCl₄诱导的肝病，尤其是预先吸入。低剂量照射诱导的抗氧化功能的充分激活很可能有助于预防或减少与生活方式疾病相关的氧化损伤。
