Graduate School of Health Sciences, Okayama University, Okayama, Japan.
Ren Fail. 2012;34(9):1181-7. doi: 10.3109/0886022X.2012.717496.
Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone's attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300-500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions.
自 2011 年福岛核事故以来，低剂量照射的影响，特别是内照射，引起了大家的关注。然而，低剂量辐射会引起各种刺激作用，如抗氧化和免疫功能的激活。在这项研究中，我们试图评估氡吸入诱导的肾脏抗氧化活性激活对四氯化碳（CCl4）诱导的肾损伤的定量影响。在吸入约 1000 或 2000 Bq/m3 氡 24 小时后，或在腹腔内（i.p.）注射α-生育酚（100、300 或 500 mg/kg 体重）后，将小鼠进行腹腔内注射 CCl4。对于肾功能，浓度为 2000 Bq/m3 的氡吸入具有与 300-500 mg/kg 体重的α-生育酚治疗相似的抑制作用。与单独用 CCl4 处理的小鼠相比，暴露于氡的小鼠肾脏中超氧化物歧化酶和过氧化氢酶的活性显著升高。这些发现表明，氡吸入具有抗氧化作用，可以对抗 CCl4 诱导的肾损伤，其作用类似于α-生育酚的抗氧化作用，这是由于抗氧化功能的诱导。
