Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Okayama 700-8558, Japan.
Mediators Inflamm. 2012;2012:382801. doi: 10.1155/2012/382801. Epub 2012 Nov 14.
We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol-induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m(3) radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol-induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol-induced hepatopathy in mice.
我们之前报道过，氡气吸入能激活肝脏的抗氧化功能，抑制四氯化碳诱导的小鼠肝损伤。此外，有报道称活性氧自由基与酒精性肝损伤有关。在这项研究中，我们研究了氡气吸入对小鼠急性酒精性肝损伤的抑制作用。C57BL/6J 小鼠吸入约 4000 Bq/m(3)氡气 24 小时后，腹腔内注射 50%酒精（5 g/kg 体重）。酒精给药显著增加了血清中谷草转氨酶（GOT）、谷丙转氨酶（GPT）的活性，以及肝组织中甘油三酯和脂质过氧化物的水平，提示急性酒精性肝损伤。氡气吸入能激活肝脏的抗氧化功能。此外，氡气预处理抑制了肝功能和抗氧化功能的降低。这些结果表明，氡气吸入激活了肝脏的抗氧化功能，抑制了小鼠急性酒精性肝损伤。
