Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rua São Francisco Xavier, 524, 7° andar, Bloco E. Cep 20550-900 Rio de Janeiro, RJ, Brazil.
Eur J Endocrinol. 2011 Jul;165(1):11-5. doi: 10.1530/EJE-11-0261. Epub 2011 May 4.
Overt hypothyroidism is clearly related to body weight gain and greater adiposity, but the range of hormonal change in serum TSH concentration associated with weight gain remains a focus of debate.
The aim of this review was to assess studies that evaluated the relationship between anthropometric measures and serum TSH concentration in euthyroid subjects.
Studies held on the Ovid MEDLINE database were searched and original articles published from 2000 to 2010 were included. The literature search was restricted to studies conducted in humans aged 18 years or older and written in English, Spanish, or Portuguese. Studies that evaluated the association between anthropometric measures and serum TSH within the normal range as the primary objective, as well as additional analysis, were included.
A total of 29 studies met the inclusion criteria. Of the 29 studies, 18 showed a positive relationship between measures of adiposity and serum TSH. Despite the plausibility of this association, only two studies reported longitudinal findings. The influence of smoking on the association between serum TSH and anthropometric measures was evaluated in only three studies and remains unclear.
Thus, further longitudinal studies are needed to better understand the mechanisms by which TSH concentration might impact body weight.
显性甲状腺功能减退症显然与体重增加和肥胖程度增加有关，但与体重增加相关的血清 TSH 浓度的激素变化范围仍然是争论的焦点。
本综述旨在评估评估甲状腺功能正常受试者的人体测量指标与血清 TSH 浓度之间关系的研究。
在 Ovid MEDLINE 数据库中进行了研究检索，并纳入了 2000 年至 2010 年发表的原始文章。文献检索仅限于对 18 岁或以上人群进行的、以英语、西班牙语或葡萄牙语撰写的研究。纳入了将人体测量指标与血清 TSH 在正常范围内的关联作为主要目标进行评估的研究，以及其他分析。
共有 29 项研究符合纳入标准。在 29 项研究中，有 18 项研究表明肥胖指标与血清 TSH 之间存在正相关关系。尽管这种关联具有合理性，但仅有两项研究报告了纵向研究结果。仅有三项研究评估了吸烟对血清 TSH 和人体测量指标之间关联的影响，其结果仍不清楚。
因此，需要进一步的纵向研究来更好地了解 TSH 浓度可能影响体重的机制。
