Verbiest H B, van Woerkom T C, Dumas A M, Bots G T, Endtz L J
Department of Neurology, Municipal Hospitals of The Hague, The Netherlands.
Clin Neurol Neurosurg. 1990;92(1):81-5. doi: 10.1016/0303-8467(90)90013-u.
A case is presented in which sensory ataxic neuronopathy developed after serologically proven infection with Rickettsia conorii and continued to be progressive after appropriate antibiotic treatment. Electrophysiological studies showed decreasing sensory nerve conduction velocities ending with the absence of sensory nerve action potentials as well as peripheral and cortical somatosensory evoked potentials. Histological studies revealed a profound loss of myelinated fibres due to primarily axonal degeneration. The clinical course and the electrophysiological and histological findings suggest primary involvement of the dorsal root ganglion. Peripheral neuropathy due to infection with R. conorii is rare and usually of the mixed motor and sensory type. We believe this to be the first report of sensory ataxic neuronopathy associated with R. conorii infection.
本文报告一例经血清学证实感染康氏立克次体后发生感觉性共济失调性神经病的病例，且在适当抗生素治疗后病情仍持续进展。电生理研究显示感觉神经传导速度降低，最终感觉神经动作电位以及外周和皮质体感诱发电位消失。组织学研究显示主要由于轴突变性导致有髓纤维严重丧失。临床病程以及电生理和组织学 findings 提示背根神经节为主要受累部位。由康氏立克次体感染引起的周围神经病较为罕见，通常为混合性运动和感觉型。我们认为这是首例与康氏立克次体感染相关的感觉性共济失调性神经病的报告。 （注：原文中“findings”未翻译，可能是输入有误，应是“结果”之类意思，这里按原文保留）
