Malinow K, Yannakakis G D, Glusman S M, Edlow D W, Griffin J, Pestronk A, Powell D L, Ramsey-Goldman R, Eidelman B H, Medsger T A
Ann Neurol. 1986 Oct;20(4):535-7. doi: 10.1002/ana.410200416.
Sensory neuropathies, particularly trigeminal neuropathy, have been recognized as neurological complications of Sjögren's syndrome, but the pathogenesis has not been established. We describe a woman with primary Sjögren's syndrome who developed a progressive debilitating subacute sensory neuronopathy. Results of electrophysiological studies were consistent with involvement of the trigeminal and dorsal root ganglia. A thoracic dorsal root ganglion biopsy showed lymphocytic infiltration and degeneration of ganglion cells. We believe that this is the first description of biopsy-documented dorsal root ganglionitis in a subacute sensory neuronopathy associated with Sjögren's syndrome and that the finding suggests an immunopathogenic basis.
感觉神经病变，尤其是三叉神经病变，已被公认为是干燥综合征的神经并发症，但发病机制尚未明确。我们描述了一位患有原发性干燥综合征的女性，她患上了一种进行性致残的亚急性感觉神经元病。电生理研究结果与三叉神经节和背根神经节受累一致。胸段背根神经节活检显示淋巴细胞浸润和神经节细胞变性。我们认为，这是首次对与干燥综合征相关的亚急性感觉神经元病中经活检证实的背根神经节炎进行描述，这一发现提示了免疫致病基础。
