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月经周期、孕期、分娩及产褥期淋巴细胞β2 - 肾上腺素能受体密度

Lymphocyte beta 2-adrenoceptor density during menstrual cycle and pregnancy, in delivery and puerperium.

作者信息

Santala M, Vilska S, Saarikoski S, Castrén O

机构信息

Department of Obstetrics and Gynaecology, Kuopio University Central Hospital, Finland.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1990 Jan-Feb;34(1-2):79-87. doi: 10.1016/0028-2243(90)90010-x.

DOI:10.1016/0028-2243(90)90010-x
PMID:2154388
Abstract

Lymphocyte beta 2-adrenoceptor density was determined in 11 women during the normal menstrual cycle and 15 women during normal pregnancy. No significant difference in lymphocyte beta 2-adrenoceptor density was established in this follow-up study during the menstrual cycle or pregnancy. Lower lymphocyte beta 2-adrenoceptor density was established just after delivery and in puerperium compared with that during pregnancy. It is likely that the high catecholamine concentration during parturition together with the duration of labour and delivery caused down-regulation of the beta 2-adrenoceptors. In puerperium the irregular day-rhythm and the stress of caring for the newborn may also have an effect.

摘要

在11名处于正常月经周期的女性和15名正常怀孕的女性中测定了淋巴细胞β2-肾上腺素能受体密度。在这项随访研究中,月经周期或怀孕期间淋巴细胞β2-肾上腺素能受体密度没有显著差异。与怀孕期间相比,产后及产褥期淋巴细胞β2-肾上腺素能受体密度较低。分娩时高浓度的儿茶酚胺以及分娩的时长可能导致了β2-肾上腺素能受体的下调。在产褥期,不规律的昼夜节律以及照顾新生儿的压力可能也有影响。

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Eur J Obstet Gynecol Reprod Biol. 1990 Jan-Feb;34(1-2):79-87. doi: 10.1016/0028-2243(90)90010-x.
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引用本文的文献

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Timing within the menstrual cycle, sex, and the use of oral contraceptives determine adrenergic suppression of NK cell activity.月经周期内的时间、性别以及口服避孕药的使用决定了肾上腺素能对自然杀伤细胞活性的抑制作用。
Br J Cancer. 2000 Dec;83(12):1630-6. doi: 10.1054/bjoc.2000.1490.
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Lymphocyte beta 2-adrenoceptors and adenosine 3':5'-cyclic monophosphate during and after normal pregnancy.正常妊娠期间及产后淋巴细胞β2 - 肾上腺素能受体与3':5'-环磷酸腺苷
Br J Pharmacol. 1993 Feb;108(2):356-62. doi: 10.1111/j.1476-5381.1993.tb12809.x.