血管内皮生长因子基因多态性与宫颈上皮内瘤变风险。

Vascular endothelial growth factor gene polymorphisms and risk of cervical intraepithelial neoplasia.

机构信息

Department of Gynecology and Gynecological Oncology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

出版信息

Int J Gynecol Cancer. 2011 May;21(4):597-601. doi: 10.1097/IGC.0b013e318214557c.

DOI:10.1097/IGC.0b013e318214557c

PMID:21543926

Abstract

OBJECTIVE

To evaluate the association between 3 vascular endothelial growth factor (VEGF) gene polymorphisms and susceptibility of cervical intraepithelial neoplasia (CIN).

MATERIALS AND METHODS

This prospectively collected case-control study investigates three common VEGF gene polymorphisms (ie, VEGF -460 [rs833061], VEGF +405 [rs2010963], and VEGF +936 [rs3025039]) in 203 women with CIN and 209 healthy women by DNA pyrosequencing. Associations between polymorphisms and CIN risk are evaluated with univariate and multivariable models and haplotype analysis.

RESULTS

In a multivariable regression model, the variant VEGF +405C allele was associated (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.2-5.1], P = 0.02) with increased susceptibility of CIN independent of number of sexual partners (OR, 2.2; 95% CI, 1.1-4.6; P = 0.03) and smoking (OR, 3.3; 95% CI, 1.6-6.6; P = 0.001). The haplotype VEGF -460C - +405C - +936C was associated with an OR of 5.2 (95% CI, 1.2-52.7) for the susceptibility of CIN.

CONCLUSIONS

The presence of the variant VEGF +405C allele and the haplotype VEGF -460C - +405C - +936C are independently associated with higher susceptibility of CIN.

摘要

目的

评估 3 种血管内皮生长因子（VEGF）基因多态性与宫颈上皮内瘤变（CIN）易感性的关系。

材料与方法

本前瞻性病例对照研究通过 DNA 焦磷酸测序，在 203 例 CIN 患者和 209 例健康女性中，调查了 VEGF 基因的 3 种常见多态性（即 VEGF-460[rs833061]、VEGF+405[rs2010963]和 VEGF+936[rs3025039]）。通过单变量和多变量模型以及单体型分析评估多态性与 CIN 风险之间的关系。

结果

在多变量回归模型中，与 VEGF+405C 等位基因变异相关（优势比[OR]，2.5；95%置信区间[CI]，1.2-5.1；P=0.02），独立于性伴侣数量（OR，2.2；95%CI，1.1-4.6；P=0.03）和吸烟（OR，3.3；95%CI，1.6-6.6；P=0.001），CIN 易感性增加。VEGF-460C-+405C-+936C 单体型与 CIN 易感性的 OR 为 5.2（95%CI，1.2-52.7）。