Jara Cecilia O, Popp Roland, Zulley Juergen, Hajak Goeran, Geisler Peter
Sleep Disorders Centre, Department of Psychiatry, Psychosomatics and Psychotherapy, University Medical Centre Regensburg, Bavaria, Germany.
J Nerv Ment Dis. 2011 May;199(5):329-34. doi: 10.1097/NMD.0b013e3182174fd3.
The present prospective study assesses depressive symptoms in narcoleptic patients with (NC+) and without (NC-) cataplexy (46 women, 40 men) and age- and sex- matched healthy controls. Seventy patients were under treatment with stimulants and/or anticataplectics. All subjects completed the Beck Depression Inventory (BDI), the Zung Self-Rating Depression Scale (SDS), the Global Impression of Severity of Depression (GSD), the Profile of Mood States (POMS) and Epworth Sleepiness Scale. Patients with narcolepsy were more depressed than controls (higher scores in BDI, GSD, SDS, and POMS [in the total score and in all subscale scores]); however, between the NC+ and NC- patient groups, no differences were found. Our study shows that the women and the patients using antidepressants and stimulants (combination) have a higher probability for depressive symptoms independent of the presence of cataplexy. The lack of difference between NC+ and NC- in the level of depression supports the assumption that the major psychosocial burden in narcolepsy is not necessarily associated with the presence of cataplexy.
本前瞻性研究评估了伴（NC+）和不伴（NC-）猝倒症的发作性睡病患者（46名女性，40名男性）以及年龄和性别匹配的健康对照者的抑郁症状。70名患者正在接受兴奋剂和/或抗猝倒药物治疗。所有受试者均完成了贝克抑郁量表（BDI）、zung自评抑郁量表（SDS）、抑郁严重程度总体印象量表（GSD）、情绪状态剖面图（POMS）和爱泼华嗜睡量表。发作性睡病患者比对照组更抑郁（BDI、GSD、SDS和POMS中的得分更高[总分及所有子量表得分]）；然而，在NC+和NC-患者组之间未发现差异。我们的研究表明，女性以及使用抗抑郁药和兴奋剂（联合使用）的患者出现抑郁症状的可能性更高，与猝倒症的存在无关。NC+和NC-在抑郁水平上缺乏差异支持了这样一种假设，即发作性睡病的主要心理社会负担不一定与猝倒症的存在相关。
