手性二胺催化的α,β-不饱和酮酯底物的不对称羟醛反应。
Asymmetric aldol reactions of α,β-unsaturated ketoester substrates catalyzed by chiral diamines.
机构信息
Laboratory of Chemical Synthesis and Pollution Control, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637009, Sichuan, China.
出版信息
Molecules. 2011 May 4;16(5):3778-86. doi: 10.3390/molecules16053778.
Abstract
Highly efficient asymmetric aldol reactions between α,β-unsaturated keto esters and acyclic ketones catalyzed by chiral diamines are reported. The corresponding products were obtained in excellent yields with excellent enantioselectivities. The absolute configuration for the product was determined by X-ray analysis. A variety of substrates were tolerable in the present catalytic system.
摘要
报道了手性二胺催化的α,β-不饱和酮酯和无环酮之间的高立体选择性不对称羟醛反应。相应的产物以优异的产率和对映选择性得到。产物的绝对构型通过 X 射线分析确定。在本催化体系中可以容忍多种底物。
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