使用二氨基亚甲基丙二腈有机催化剂对β-酮酯进行不对称氯化反应。
Asymmetric Chlorination of β-Keto Esters Using Diaminomethylenemalononitrile Organocatalyst.
作者信息
Sakai Takaaki, Hirashima Shin-Ichi, Nakashima Kosuke, Maeda Chie, Yoshida Akihiro, Koseki Yuji, Miura Tsuyoshi
机构信息
Tokyo University of Pharmacy and Life Sciences.
出版信息
Chem Pharm Bull (Tokyo). 2016;64(12):1781-1784. doi: 10.1248/cpb.c16-00722.
PMID:27904086
Abstract
Diaminomethylenemalononitrile organocatalysts promote the asymmetric chlorination of simple cyclic β-keto esters such as methyl, ethyl, and benzyl esters of 1-oxo-2,3-dihydro-1H-indene-2-carboxylic acid. This affords the corresponding chiral α-chlorinated carbonyl products in excellent yields with high enantioselectivities.
摘要
二氨基亚甲基丙二腈有机催化剂促进简单环状β-酮酯（如1-氧代-2,3-二氢-1H-茚-2-羧酸的甲酯、乙酯和苄酯）的不对称氯化反应。这能以优异的产率和高对映选择性得到相应的手性α-氯化羰基产物。
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