Arslan Mehmet, Demir Halit, Arslan Harun, Gokalp A Samet, Demir Canan
Department of Neurosurgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
Asian Pac J Cancer Prev. 2011;12(2):447-51.
We aimed to assess relevance of mineral, trace element and heavy metal levels in patients with malignant gliomas.
In this study, erythrocyte catalase (CAT), and carbonic anhydrase (CA), serum copper (Cu.), zinc (Zn), lead (Pb), iron (Fe), cadmium (Cd), cobalt (Co), manganese (Mn), and magnesium (Mg) levels were measured in 22 healthy humans and 22 malignant glioma patients. Metal concentrations were assessed by atomic adsorption spectrophotometry, while biochemical methods were used for CAT and CA.
The Cd, Fe, Mg, Mn, Pb and Zn levels were significantly elevated in the patients as a whole compared to controls(P<0.05), while Cu was decreased and Co demonstrated no change. Although mean CAT activity were significantly lowered, CA exhibited significant increase.
The results of the current study indicate that antioxidant enzymes may have a role in the genesis of considerable oxidative stress in patients with malignant glioma. CAT and CA seem to play particular roles in the pathophysiology of this disease.
我们旨在评估恶性胶质瘤患者体内矿物质、微量元素和重金属水平的相关性。
在本研究中，对22名健康人和22名恶性胶质瘤患者测量了红细胞过氧化氢酶（CAT）、碳酸酐酶（CA）、血清铜（Cu）、锌（Zn）、铅（Pb）、铁（Fe）、镉（Cd）、钴（Co）、锰（Mn）和镁（Mg）的水平。通过原子吸收分光光度法评估金属浓度，而采用生化方法检测CAT和CA。
与对照组相比，总体患者的镉、铁、镁、锰、铅和锌水平显著升高（P<0.05），而铜水平降低，钴水平无变化。虽然平均CAT活性显著降低，但CA表现出显著增加。
本研究结果表明，抗氧化酶可能在恶性胶质瘤患者显著的氧化应激发生过程中发挥作用。CAT和CA似乎在该疾病的病理生理学中发挥特殊作用。
