Kaba Mehmet, Pirinççi Necip, Yüksel Mehmet Bilgehan, Gecit İlhan, Güneş Mustafa, Demir Murat, Akkoyun HurremTuran, Demir Halit
Department of Urology,Faculty of Medicine,Yuzuncu Yıl University, Van, Turkey.
Department of Urology,Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
Int Braz J Urol. 2015 Nov-Dec;41(6):1101-7. doi: 10.1590/S1677-5538.IBJU.2014.0460.
Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions.
In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9±11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4±10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20ºC until assays.
In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05).
These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.
微量元素是生物结构的主要组成部分；然而，当它们的浓度高于生物功能所需浓度时，可能具有毒性。
在本研究中，使用火焰原子吸收分光光度计对30例新诊断为睾丸生殖细胞癌的患者（平均年龄26.9±11.2岁）和32名健康志愿者（平均年龄：27.4±10.8）的血清微量元素水平进行了测量。血清样本在-20℃保存直至检测。
在睾丸生殖细胞癌患者中，诊断为精原细胞瘤的有15例，混合性生殖细胞肿瘤7例，胚胎癌4例，卵黄囊瘤2例，畸胎瘤2例。19例患者（63.3%）为Ⅰ期睾丸肿瘤，6例（20.0%）为Ⅱ期，4例（13.3%）为ⅢA期，1例（3.4%）为ⅡC期。结果发现，睾丸癌患者血清钴、铜、镁和铅水平升高（p<0.05），而铁、锰和锌水平降低（p<0.05）。
这些改变可能在睾丸癌的发病机制中具有重要意义；然而，需要进一步的前瞻性研究来确定睾丸癌与微量元素之间的关系。
