Cobb C M, Eick J D, Barker B F, Mosby E L, Hiatt W R
Department of Oral Biology, University of Missouri-Kansas City School of Dentistry 64108.
J Oral Maxillofac Surg. 1990 Mar;48(3):268-75. doi: 10.1016/0278-2391(90)90392-f.
The purpose of this investigation was to assess by light, transmission, and scanning electron microscopy the healing of mandibular continuity defects reconstructed with varying ratios of an alloplastic hydroxylapatite implant material (HA) mixed with autogenous bone (AB). This study reports the microscopic observations of implant and control sites at 6 and 18 months postsurgery. The results confirm the biocompatibility of dense HA granules. Specimens exhibited differing degrees of osseous regeneration that appeared related to the percent composition of HA. At 18 months, 86% and 91% of the HA granules were completely surrounded by bone in those specimens reconstructed with implants consisting of 25% and 50% HA, respectively. In contrast, specimens receiving implants consisting of 75% and 100% HA features osseous encapsulation of 75% and 66% of the granules, respectively. The results of this limited study indicate that dense HA granules mixed with AB in ratios ranging from 3:1 to 1:1 (AB:HA) may be successfully used as a bone extender during reconstructive surgery.
本研究的目的是通过光学显微镜、透射电子显微镜和扫描电子显微镜，评估用不同比例的异体羟基磷灰石植入材料（HA）与自体骨（AB）混合重建下颌连续性缺损后的愈合情况。本研究报告了术后6个月和18个月时植入部位和对照部位的微观观察结果。结果证实了致密HA颗粒的生物相容性。标本显示出不同程度的骨再生，这似乎与HA的百分比组成有关。在18个月时，分别用含25%和50%HA的植入物重建的标本中，86%和91%的HA颗粒被骨完全包围。相比之下，接受含75%和100%HA植入物的标本中，分别有75%和66%的颗粒被骨包裹。这项有限研究的结果表明，在重建手术中，以3:1至1:1（AB:HA）比例混合AB的致密HA颗粒可成功用作骨增量材料。
