Eick J D, Bear L, Cobb C M, Mosby E L, Hiatt W R
Department of Oral Biology, School of Dentistry, University of Missouri-Kansas City, Kansas City 64108-2795.
J Oral Maxillofac Surg. 1990 Aug;48(8):823-30. doi: 10.1016/0278-2391(90)90341-x.
The purpose of this investigation was to determine the mechanical behavior of primate (Macaca mulatta) mandibles with continuity defects reconstructed using varying ratios of an alloplastic hydroxylapatite (HA) implant material mixed with autogenous bone (AB). The defects were allowed to heal for 6 and 18 months before killing the animals and mechanical testing. Each animal had one side of the mandible restored with 100% AB as control. The fracture strength and section modulus of the opposite side of the mandible, containing the test ratio of HA-AB, were directly compared with the mechanical behavior of the control side. The fracture strength and section modulus were evaluated by a cantilever type of mechanical test that took into account the anisotropic, viscoelastic, and geometric nature of the mandible. The type of bone and tissue at the fracture site was examined by scanning electron microscopy and a direct correlation between the amount of bone and/or fibrous tissue growth around the HA implant material and the fracture strength and section modulus values was established. The average fracture strength of the AB graft sites at 18 months was 9,975 +/- 4,300 psi, with ratios of 25:75 and 50:50 HA-AB giving test results approaching those of the AB graft sites.
本研究的目的是确定使用不同比例的异质羟基磷灰石（HA）植入材料与自体骨（AB）混合重建的灵长类动物（猕猴）下颌骨连续性缺损的力学行为。在处死动物并进行力学测试之前，让缺损愈合6个月和18个月。每只动物的下颌骨一侧用100%的自体骨修复作为对照。将含有HA-AB测试比例的下颌骨另一侧的断裂强度和截面模量与对照侧的力学行为直接进行比较。通过考虑下颌骨各向异性、粘弹性和几何性质的悬臂式力学测试来评估断裂强度和截面模量。通过扫描电子显微镜检查骨折部位的骨和组织类型，并确定HA植入材料周围骨和/或纤维组织生长量与断裂强度和截面模量值之间的直接相关性。18个月时自体骨移植部位的平均断裂强度为9,975 +/- 4,300磅力/平方英寸，HA-AB比例为25:75和50:50时的测试结果接近自体骨移植部位的结果。
