Department of Haematology & Transfusion Medicine, Bolan Medical College Complex, Quetta, Balochistan, Pakistan.
Saudi J Gastroenterol. 2011 May-Jun;17(3):180-4. doi: 10.4103/1319-3767.80380.
BACKGROUND/AIM: The objective was to evaluate the sero-prevalence of hepatitis B surface antigen (HBsAg) and IgM antibodies to hepatitis core antigen in Balochistan Province of Pakistan.
A cross-sectional, population-based study. Place and time of the study: The study was conducted in Balochistan from 1 st January 2004 to 31 st December, 2008. The screening areas included Barkhan, Eashani, Khuzdar, Kodi Zikriani, Kohlu, Rakhni and Turbat.
A total of 15,260 subjects were enrolled; 11,900 (78%) agreed to undergo screening. Fresh serum samples were tested for the presence of hepatitis B surface antigen and IgM antibodies to hepatitis B core antigen.
HBsAg was detected in 1166 (9.8%) while anti-HBc IgM was found in 117 (10.0%). HBsAg positivity was seen in 875 (12.7%) males and 291 (5.8%) females. The prevalence of hepatitis B in Balochistan varies from 3.3% in Khuzdar to 17.0% in Kodi Zikriani.
It is utmost important to educate the public, to take proper measures to control the spread of infection and vaccination in order to interrupt transmission of this threatening public health problem in Balochistan province of Pakistan.
背景/目的：本研究旨在评估巴基斯坦俾路支省乙型肝炎表面抗原（HBsAg）和乙型肝炎核心抗原 IgM 抗体的血清流行率。
横断面、基于人群的研究。
本研究于 2004 年 1 月 1 日至 2008 年 12 月 31 日在俾路支省进行。筛查区域包括巴尔坎、埃沙尼、胡兹达尔、科迪齐克里安尼、科勒、拉赫尼和图尔巴特。
共纳入 15260 名受试者；11900 名（78%）同意接受筛查。采集新鲜血清样本检测乙型肝炎表面抗原和乙型肝炎核心抗原 IgM 抗体。
检出 HBsAg1166 例（9.8%），抗-HBc IgM 阳性 117 例（10.0%）。HBsAg 阳性率在男性中为 12.7%（875 例），在女性中为 5.8%（291 例）。俾路支省乙型肝炎的流行率从胡兹达尔的 3.3%到科迪齐克里安尼的 17.0%不等。
在俾路支省，教育公众、采取适当措施控制感染传播和接种疫苗以阻断这一威胁公众健康问题的传播至关重要。
