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2型糖尿病患者中触珠蛋白基因变异与视网膜病变的关联：一项荟萃分析。

The Association of Haptoglobin Gene Variants and Retinopathy in Type 2 Diabetic Patients: A Meta-Analysis.

作者信息

Wu Huiqun, Wu Huan, Shi Lili, Yuan Xinlu, Yin Ying, Yuan Mingjie, Zhou Yushan, Hu Qianwen, Jiang Kui, Dong Jiancheng

机构信息

Department of Medical Informatics, Medical School of Nantong University, Nantong 226001, China.

Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.

出版信息

J Diabetes Res. 2017;2017:2195059. doi: 10.1155/2017/2195059. Epub 2017 Jul 3.

DOI:10.1155/2017/2195059
PMID:28758129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5512055/
Abstract

AIMS/INTRODUCTION: To collectively evaluate the association between haptoglobin (Hp) gene variants and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

METHODS

A comprehensive literature review was performed for eligible studies. After inclusion and exclusion selection as well as quality assessment, those studies meeting quality standards were included. In this study, diabetic patients with retinopathy were selected as the case group and those ones without DR were treated as the control group. The recessive model, allele model, additive model, heterozygote model, and homozygote model were utilized to investigate the association of three Hp gene variants and DR. Subgroup analysis on different severity of DR including nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) was also conducted.

RESULTS

Six trials from different regions were finally included. A total of 1145 subjects containing 564 T2DM patients with retinopathy were included. The recessive model, allele model, additive model, and homozygote model results showed that Hp gene variants were not associated with DR, NPDR, and PDR. However, the heterozygote model indicated the association of Hp gene variants with DR.

CONCLUSIONS

No association was found between the Hp gene variants and PDR and NPDR. More studies are required to verify these findings.

摘要

目的/引言：综合评估2型糖尿病（T2DM）患者中触珠蛋白（Hp）基因变异与糖尿病视网膜病变（DR）之间的关联。

方法

对符合条件的研究进行全面的文献综述。经过纳入和排除筛选以及质量评估后，纳入符合质量标准的研究。本研究中，将患有视网膜病变的糖尿病患者选为病例组，将无DR的患者作为对照组。采用隐性模型、等位基因模型、加性模型、杂合子模型和纯合子模型来研究三种Hp基因变异与DR的关联。还对不同严重程度的DR进行亚组分析，包括非增殖性糖尿病视网膜病变（NPDR）和增殖性糖尿病视网膜病变（PDR）。

结果

最终纳入来自不同地区的六项试验。总共纳入了1145名受试者，其中包括564名患有视网膜病变的T2DM患者。隐性模型、等位基因模型、加性模型和纯合子模型结果显示，Hp基因变异与DR、NPDR和PDR均无关联。然而，杂合子模型表明Hp基因变异与DR有关联。

结论

未发现Hp基因变异与PDR和NPDR之间存在关联。需要更多研究来验证这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/fed465d070a3/JDR2017-2195059.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/1dc8b36edb2c/JDR2017-2195059.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/d288342f17f2/JDR2017-2195059.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/9c77baa4f5f1/JDR2017-2195059.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/a3bae2bc6523/JDR2017-2195059.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/75f2568e58a4/JDR2017-2195059.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/27386107d8c8/JDR2017-2195059.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/54510bbf69a1/JDR2017-2195059.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/ca9680a76f05/JDR2017-2195059.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/fed465d070a3/JDR2017-2195059.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/1dc8b36edb2c/JDR2017-2195059.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/d288342f17f2/JDR2017-2195059.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/9c77baa4f5f1/JDR2017-2195059.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/a3bae2bc6523/JDR2017-2195059.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/75f2568e58a4/JDR2017-2195059.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/27386107d8c8/JDR2017-2195059.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/54510bbf69a1/JDR2017-2195059.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/ca9680a76f05/JDR2017-2195059.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3bb/5512055/fed465d070a3/JDR2017-2195059.009.jpg

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