Department of Surgery, University of Washington, Seattle, WA, USA.
J Perinatol. 2012 Jan;32(1):45-50. doi: 10.1038/jp.2011.49. Epub 2011 May 5.
Interpregnancy interval (IPI) influences numerous adverse perinatal outcomes. IPI's impact on birth defects is unclear.
We conducted a population-based case-control study, using 1998 to 2008 administrative data from Washington State. A total of 10, 772 cases, women whose second of two births resulted in an infant with a birth defect, were compared with 32 ,310 controls, women whose second of two births did not result in an infant with a birth defect.
Compared with mothers with an IPI between 18 to 23 months, those with an IPI <6 months or ≥60 months had elevated risks of delivering an infant with a birth defect (odds ratio=1.15, 95% confidence interval: 1.03 to 1.28, and odds ratio=1.15, 95% confidence interval: 1.04 to 1.26, respectively).
We observed a J-shaped relationship between IPI and risk of having an infant with a birth defect. As this is one of the first studies to evaluate this association, confirmatory studies are needed.
妊娠间隔（interpregnancy interval，IPI）会影响许多不良围产期结局。IPI 对出生缺陷的影响尚不清楚。
我们进行了一项基于人群的病例对照研究，使用了 1998 年至 2008 年来自华盛顿州的行政数据。共有 10772 例病例，即第二次分娩的婴儿有出生缺陷的女性，与 32310 例对照，即第二次分娩的婴儿没有出生缺陷的女性进行了比较。
与 IPI 在 18 至 23 个月之间的母亲相比，IPI<6 个月或≥60 个月的母亲生育有出生缺陷的婴儿的风险增加（比值比=1.15，95%置信区间：1.03 至 1.28，和比值比=1.15，95%置信区间：1.04 至 1.26）。
我们观察到 IPI 与出生缺陷风险之间存在 J 形关系。由于这是评估这种关联的首批研究之一，因此需要进行确证性研究。
