Nat Med. 2011 May;17(5):547-8. doi: 10.1038/nm0511-547.
Moderate to severe asthma is difficult to treat because recurring bouts of inflammation in the lungs induce fibrosis, which reduces lung elasticity, gas exchange and responses to conventional therapy. A recent study identifies the tumor necrosis factor family member LIGHT as an essential mediator of airway fibrosis in a mouse model of chronic asthma (pages 596–603).
中度至重度哮喘难以治疗，因为肺部反复发生的炎症会导致纤维化，从而降低肺弹性、气体交换和对常规治疗的反应。最近的一项研究确定肿瘤坏死因子家族成员 LIGHT 是慢性哮喘小鼠模型中气道纤维化的重要介质（第 596-603 页）。
