星形胶质细胞中的突触可塑性与钙离子信号传导
Synaptic plasticity and Ca2+ signalling in astrocytes.
作者信息
Henneberger Christian, Rusakov Dmitri A
机构信息
UCL Institute of Neurology, University College London, Queen Square, London WC1N 2BG, UK.
出版信息
Neuron Glia Biol. 2010 Aug;6(3):141-6. doi: 10.1017/S1740925X10000153. Epub 2010 Oct 13.
Abstract
There is a growing body of evidence suggesting a functional relationship between Ca2+ signals generated in astroglia and the functioning of nearby excitatory synapses. Interference with endogenous Ca2+ homeostasis inside individual astrocytes has been shown to affect synaptic transmission and its use-dependent changes. However, establishing the causal link between source-specific, physiologically relevant intracellular Ca2+ signals, the astrocytic release machinery and the consequent effects on synaptic transmission has proved difficult. Improved methods of Ca2+ monitoring in situ will be essential for resolving the ambiguity in understanding the underlying Ca2+ signalling cascades.
摘要
越来越多的证据表明，星形胶质细胞中产生的Ca2+信号与附近兴奋性突触的功能之间存在功能关系。已表明干扰单个星形胶质细胞内的内源性Ca2+稳态会影响突触传递及其使用依赖性变化。然而，证明源特异性、生理相关的细胞内Ca2+信号、星形胶质细胞释放机制与对突触传递的后续影响之间的因果联系已被证明是困难的。改进的原位Ca2+监测方法对于解决理解潜在Ca2+信号级联中的模糊性至关重要。
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