Nenoff P, Arnold T, Nenning H, Hindermann W
Haut- und Laborarzt/Allergologie, Andrologie, Labor für medizinische Mikrobiologie, Straße des Friedens 8, 04579, Mölbis, Deutschland.
Hautarzt. 2011 Jul;62(7):544-7. doi: 10.1007/s00105-011-2171-4.
A 62-year-old man presented with slowly progredient, centrifugal, peripherally hyperkeratotic, centrally atrophic, slightly pruritic lesions on his scalp for at least 9 months. A punch biopsy stained with hematoxylin-eosin (HE) revealed minimal epidermal acanthosis and chimney-like parakeratosis (cornoid lamella) around a follicle. Discrete spongiosis of the epidermis was observed, as well as a lymphocytic cell infiltration in the papillary dermis. Based on the clinical picture and the histopathological examination the diagnosis of porokeratosis of Mibelli was made. Topical treatment was started using an urea and vitamin A acid preparation.
一名62岁男性，头皮出现缓慢进展的、离心性的、周边角化过度、中央萎缩且轻度瘙痒的皮损，病程至少9个月。苏木精-伊红（HE）染色的皮肤活检显示表皮棘层轻度增厚，毛囊周围有烟囱样角化不全（角质样板层）。观察到表皮有散在的海绵形成，以及乳头真皮层有淋巴细胞浸润。根据临床表现和组织病理学检查，诊断为米贝利汗孔角化症。开始使用尿素和维甲酸制剂进行局部治疗。
