Department of Psychiatry, The University of Western Ontario, Rm. 114A-WMCH Bldg, 392 South Street, London, ON Canada N6A 4G5.
Schizophr Res. 2011 Jul;129(2-3):111-5. doi: 10.1016/j.schres.2011.04.006. Epub 2011 May 5.
There continues to be controversy concerning the long term benefits of specialized early intervention programs (SEI) for psychotic disorders. Recent reports of five year outcomes for SEI programs indicate that benefits of early intervention programs at two year follow-up have disappeared at five years. The Prevention and Early Intervention Program for Psychoses (PEPP) in London, Ontario offers continuity of care for five years, with a lower intensity level of specialized intervention after the initial two years. In this paper we examine whether the outcomes observed at two years were maintained at five year follow-up. In addition, it was possible to compare PEPP outcomes with those of the OPUS project at two and five years. Results indicate that improvement of symptoms between entry into PEPP and two year follow-up were maintained at five years. In addition, there was further improvement in global functioning between two and five year follow-up. Comparison of PEPP outcomes at two and five year follow-up to those of OPUS suggest that longer term continuity of care within SEI is associated with continuing benefits at least with respect to level of positive symptoms and functioning.
关于精神病的专门早期干预项目(SEI)的长期益处,一直存在争议。最近关于 SEI 项目五年结果的报告表明,在两年随访时早期干预项目的益处已经在五年时消失。安大略省伦敦的精神病预防和早期干预项目(PEPP)为患者提供五年的连续护理,在最初的两年之后,专门干预的强度水平较低。在本文中,我们研究了在五年随访时是否维持了两年时观察到的结果。此外,还可以将 PEPP 的结果与 OPUS 项目的结果在两年和五年时进行比较。结果表明,进入 PEPP 与两年随访之间症状改善在五年时得以维持。此外,在两年和五年随访之间,整体功能进一步改善。将 PEPP 在两年和五年随访时的结果与 OPUS 的结果进行比较表明,在 SEI 中进行更长期的连续性护理至少与阳性症状和功能的水平相关,与持续的益处相关。