The Foot and Ankle Service, Department of Trauma & Orthopaedic Surgery, Royal Infirmary, 51, Little France Crescent, Edinburgh EH16 4SA, United Kingdom.
Foot Ankle Surg. 2011 Jun;17(2):e34-6. doi: 10.1016/j.fas.2011.01.011. Epub 2011 Feb 22.
Black bone disease is a rare manifestation of long term treatment with tetracyclines. We report the case of a patient who underwent surgery for bilateral hallux valgus and was found to have black discolouration of both first rays. This was subsequently related to previous long term Minocycline use. The unique features of this case relate to the location of the discolouration and the normal physical properties of the bone and soft tissues at surgery despite heavy pigmentation. Healing is now complete and follow-up at two years confirmed excellent clinical and radiological outcomes.
黑骨病是长期使用四环素类药物治疗的一种罕见表现。我们报告了一例接受双侧拇外翻手术的患者，发现其两个第一跖骨均有黑色变色。这随后与之前长期使用米诺环素有关。该病例的独特特征与变色的位置以及骨骼和软组织的正常物理特性有关，尽管色素沉着严重。目前已完全愈合，两年随访证实了良好的临床和影像学结果。
