Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy.
Ann Oncol. 2012 Feb;23(2):287-97. doi: 10.1093/annonc/mdr136. Epub 2011 May 5.
In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data.
We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models.
The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (≤ 1 drink per day), 0.90 for moderate (1 to < 4 drinks per day), and 1.16 for heavy (≥ 4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was < 1 up to 70 g/day.
This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption.
为了准确量化饮酒与食管和胃贲门腺癌风险之间的关联，我们对现有数据进行了荟萃分析。
我们确定了 20 项病例对照研究和 4 项队列研究，共包括 5500 例病例。我们使用随机效应模型得出荟萃分析估计值，考虑到估计值之间的相关性，并使用非线性随机效应荟萃回归模型进行剂量-风险分析。
与非饮酒者相比，饮酒者的相对风险（RR）总体为 0.96（95%置信区间 0.85-1.09），食管腺癌为 0.87（95%置信区间 0.74-1.01），胃贲门腺癌为 0.89（95%置信区间 0.76-1.03）。与非饮酒者相比，轻（≤ 1 份/天）、中（1-<4 份/天）和重（≥ 4 份/天）饮酒者的汇总 RR 分别为 0.86、0.90 和 1.16。剂量-风险模型发现每日 25 克为最低值，曲线在 70 克/天以下。
这项荟萃分析提供了明确的证据，表明饮酒与食管和胃贲门腺癌风险之间不存在关联，即使在较高的饮酒剂量下也是如此。
