Gelister J S, Boulos P B, Gaffney P J, Mahmoud M, Lewin M R
Department of Surgery, Faculty of Clinical Sciences, University College London, Rayne Institute.
Eur J Surg Oncol. 1990 Feb;16(1):54-9.
Accruing evidence suggests an association between increased activity of plasminogen activators and transformed cells, and urokinase activity with tumour aggressiveness. The PIP2 pathway seems to provide a link between oncogene-associated transformation, cellular proliferation, plasminogen-activator expression and tumour invasion and metastasis.
越来越多的证据表明，纤溶酶原激活剂活性增加与转化细胞之间存在关联，尿激酶活性与肿瘤侵袭性之间也存在关联。磷脂酰肌醇-4,5-二磷酸（PIP2）途径似乎在癌基因相关的转化、细胞增殖、纤溶酶原激活剂表达以及肿瘤侵袭和转移之间提供了一种联系。
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