Neurology Research Laboratory, Durham Department of Veterans' Affairs Medical Center, Durham, NC (U.S.A.) Department of Medicine, (Neurology), Duke University Durham, NC (U.S.A.).
Restor Neurol Neurosci. 1990 Jan 1;1(5):311-4. doi: 10.3233/RNN-1990-1501.
Treatment with amphetamine increases the rate of recovery of beam-walking in rats when administered after a unilateral suction-ablation lesion of the sensorimotor cortex. It is thought that amphetamine treatment must be combined with postlesion practice on the beam since confinement to prevent locomotion blocks amphetamine-facilitated recovery. However, rats which are confined are also isolated and not handled. In the present experiment, beam-walking recovery was compared among groups of rats which were treated with either amphetamine or saline and then either handled and allowed to walk in a home cage or given practice on the beam. Although amphetamine treatment and postlesion practice had independent beneficial effects on recovery, the group of rats given both treatments had the greatest improvement in beam-walking scores.
安非他命治疗后感觉运动皮层单侧抽吸损伤的大鼠在光束上的行走速度恢复率增加。人们认为，安非他命治疗必须与光束上的损伤后练习相结合，因为限制运动可阻止安非他命促进的恢复。然而，被限制的大鼠也被隔离且不被处理。在本实验中，比较了接受安非他命或生理盐水治疗然后被处理并允许在笼中行走或在光束上进行练习的大鼠的光束行走恢复情况。尽管安非他命治疗和损伤后练习对恢复有独立的有益作用，但接受两种治疗的大鼠的光束行走评分改善最大。
