Huang D P, Ho J H, Ng M H
IARC Sci Publ (1971). 1978(20):359-68.
Tissue fragments of fresh biopsy specimens from the non-neoplastic NP mucosa of 20 subjects, from the tumours of 10 NPC patients, from the mucosa of freshly removed tonsils from nine subjects and from the primary lesions of seven patients with malignancies of the upper respiratory or alimentary tract other than NPC were infected with EBV derived from B95-8 cells. A significantly higher frequency of growth stimulation and a greater mean growth ratio between infected and uninfected fragments from the same source were observed in the non-neoplastic NP mucosa specimens than in the others. In addition, the growth characteristics and the morphology of the cells in the infected non-neoplastic NP mucosal explants resembled those of transformed cells; but whether they possess malignant potential is being investigated.
来自20名受试者非肿瘤性鼻咽黏膜的新鲜活检标本组织碎片、10名鼻咽癌患者肿瘤组织碎片、9名受试者新鲜切除扁桃体的黏膜组织碎片以及7名非鼻咽癌的上呼吸道或消化道恶性肿瘤患者的原发灶组织碎片，均用源自B95 - 8细胞的EBV进行感染。与其他组织相比，在非肿瘤性鼻咽黏膜标本中，观察到来自同一来源的感染片段与未感染片段之间生长刺激频率显著更高，且平均生长率更大。此外，感染的非肿瘤性鼻咽黏膜外植体中细胞的生长特性和形态类似于转化细胞；但其是否具有恶性潜能正在研究中。
