Department of Stroke Rehabilitation, Loewenstein Rehabilitation Hospital, Raanana and Sackler School of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel.
Restor Neurol Neurosci. 1995 Jan 1;9(1):7-13. doi: 10.3233/RNN-1995-9102.
Experimental animals with large posterior-cortical lesions develop disturbances of visual perception and visually-guided behavior in the contralateral space, resembling the syndrome of unilateral spatial neglect (USN) in humans. The visuo-motor performance in the ignored space is recovered some time following additional lesion inflicted to the contralesional superior colliculus (SC) or section of the intercollicular pathways. Based on the model that explains this recovery by disinhibition of the ipsilesional SC (the 'Sprague effect') Posner and Rafal [37] proposed that ipsilesional monocular occlusion could possibly reduce the 'tone' of contralesional collicular neurons thereby removing an important contributor of hemineglect. A group of twenty-six right-hemisphere-damaged patients with USN was given a cancellation task under binocular and monocular (left and right) viewing conditions. Thirteen patients showed amelioration of left hemineglect in conditions of left-monocular viewing, as compared to the baseline binocular state. Although this result superficially resembles the Sprague effect, two patients benefited from right-monocular viewing whereas eleven patients showed no significant change in either right or left viewing conditions. The possible role of structures mediating interocular differences in target detection in cases of right hemisphere damage is discussed. It is suggested that even if the Sprague effect contributes to the salubrious influence of monocular viewing it is hardly the single factor involved.
实验动物的大皮质后病变发展中的干扰视觉感知和视觉引导行为在对侧空间，类似于单侧空间忽略（USN）的综合征在人类。的视动表现忽略空间恢复一段时间后另外损害造成的对侧上丘（SC）或部分的脑桥间径路。基于模型解释这种复苏的抑制解除同侧的 SC （的'斯普拉格效应'）Posner 和 Rafal [37]提出同侧单眼闭合可能会减少'口气'同侧的丘神经元从而消除了hemineglect 的一个重要贡献者。一组 26 例右侧半球损伤的患者与 USN 被给予取消任务下的双眼和单眼（左和右）查看条件。 13 例患者的改善了左忽视在左眼单眼观看条件下，与基线双眼状态相比。虽然这个结果表面上类似于斯普拉格效应，2 例患者受益于右眼单眼观看而 11 例患者在任何一侧观看条件下都没有明显变化。可能的作用结构调解眼间差异在目标检测的情况下，右半球损伤的讨论。建议即使斯普拉格效应有助于有益的影响单眼观看，它几乎不是唯一的因素。
