Rudolf Magnus Institute for Neurosciences of the Utrecht University, Department of Medical Pharmacology, Postbus 80040, 3508 TA Utrecht, The Netherlands Utrecht University Hospital, Center for Nutritional and Rehabilitation Sciences, Utrecht, The Netherlands.
Restor Neurol Neurosci. 1996 Jan 1;10(2):85-93. doi: 10.3233/RNN-1996-10204.
The effect of moderate exercise training on acute and chronic neuropathy in two separate experiments was examined. Acute nerve dysfunction was induced by sciatic nerve crush lesion and chronic neuropathy by streptozotocin-induced diabetes mellitus (experimental diabetic neuropathy; EDN). Moderate exercise training was achieved by placing food and water, separately, at either end of a U-shaped tubular home cage (8 m). Recovery from the crush lesion and the development of EDN were monitored by evaluating the free walking pattern and nerve conduction velocity (NCV), respectively. In the acute neuropathy model, 24 days of exercise after the crush lesion resulted in an enhanced return of motor function in the early phase of recovery (P < 0.01) and an increased sensory NCV after 250 days in the late phase (P < 0.001). Diabetic rats benefited from this exercise training by showing fewer signs of EDN, as evidenced by a superior motor function (toespreading, calculated from the free walking pattern; P < 0.05) and an improvement in both motor and sensory NCV (both P < 0.05). We conclude that moderate exercise training is effective in enhancing recovery from acute peripheral neuropathy and in ameliorating the consequences of experimental chronic neuropathy in diabetic rats.
在两个独立的实验中，研究了中等强度运动训练对急性和慢性周围神经病的影响。通过坐骨神经挤压损伤诱导急性神经功能障碍，通过链脲佐菌素诱导的糖尿病（实验性糖尿病周围神经病；EDN）诱导慢性周围神经病。通过将食物和水分别放置在 U 形管状笼的两端来实现中等强度的运动训练（8 m）。通过评估自由行走模式和神经传导速度（NCV）分别监测挤压损伤后的恢复情况和 EDN 的发展情况。在急性神经病模型中，挤压损伤后 24 天的运动训练导致运动功能在恢复的早期阶段得到增强（P < 0.01），并且在后期阶段（250 天后）感觉 NCV 增加（P < 0.001）。糖尿病大鼠从这种运动训练中受益，表现出较少的 EDN 迹象，这表现为运动功能更好（从自由行走模式计算的足趾伸展；P < 0.05），以及运动和感觉 NCV 的改善（均 P < 0.05）。我们得出结论，中等强度的运动训练可有效促进急性周围神经病的恢复，并改善糖尿病大鼠实验性慢性周围神经病的后果。
