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转移性胃癌治疗的新进展：聚焦于曲妥珠单抗。

New developments in the treatment of metastatic gastric cancer: focus on trastuzumab.

作者信息

Rose Jeffrey S, Bekaii-Saab Tanios S

机构信息

Department of Internal Medicine, Division of Medical Oncology, The Ohio State University - Arthur James Cancer Hospital, Columbus, OH, USA.

出版信息

Onco Targets Ther. 2011 Mar 24;4:21-6. doi: 10.2147/OTT.S10188.

DOI:10.2147/OTT.S10188
PMID:21552412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3084304/
Abstract

Patients with metastatic gastric cancer have a poor outcome. The development of new combinations of chemotherapy has led to steady but only modest gains in overall survival with largest effects reported with two- and three-drug regimens. Trastuzumab, a fully humanized monoclonal antibody directed at the human epidermal growth factor receptor-2 (HER2), has been found to improve response rate and survival in patients with advanced gastric cancer. This update will review the role of HER2 and summarize therapeutic advances in the use of trastuzumab in advanced gastric cancer.

摘要

转移性胃癌患者的预后较差。新的化疗联合方案的研发使总生存期稳步提高，但幅度有限，两药和三药方案的疗效最为显著。曲妥珠单抗是一种针对人表皮生长因子受体2（HER2）的全人源化单克隆抗体，已被发现可提高晚期胃癌患者的缓解率并延长生存期。本综述将阐述HER2的作用，并总结曲妥珠单抗在晚期胃癌治疗中的进展。

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本文引用的文献

1
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial.曲妥珠单抗联合化疗与单纯化疗治疗 HER2 阳性晚期胃或胃食管交界腺癌（ToGA）：一项开放标签、随机对照的 3 期临床试验。
Lancet. 2010 Aug 28;376(9742):687-97. doi: 10.1016/S0140-6736(10)61121-X. Epub 2010 Aug 19.
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Efficacy of trastuzumab in routine clinical practice and after progression for metastatic breast cancer patients: the observational Hermine study.曲妥珠单抗在转移性乳腺癌患者常规临床实践及进展后的疗效：观察性 Hermine 研究。
Oncologist. 2010;15(8):799-809. doi: 10.1634/theoncologist.2009-0029. Epub 2010 Jul 29.
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HER2 expression in gastric cancer: Rare, heterogeneous and of no prognostic value - conclusions from 924 cases of two independent series.胃癌中HER2的表达：罕见、异质性且无预后价值——来自两个独立系列924例病例的结论
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A phase I trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignancies.紫杉醇和曲妥珠单抗联合白细胞介素-12 治疗 HER2/neu 表达的恶性肿瘤的 I 期临床试验。
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Comparative study on overexpression of HER2/neu and HER3 in gastric cancer.胃癌中HER2/neu和HER3过表达的比较研究
World J Surg. 2009 Oct;33(10):2112-8. doi: 10.1007/s00268-009-0142-z.
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Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.新型抗癌靶点：重新审视ERBB2并发现ERBB3。
Nat Rev Cancer. 2009 Jul;9(7):463-75. doi: 10.1038/nrc2656. Epub 2009 Jun 18.
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Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a german breast group 26/breast international group 03-05 study.曲妥珠单抗用于人表皮生长因子受体2阳性晚期乳腺癌进展后的治疗：德国乳腺癌研究组26/国际乳腺癌研究组03-05研究
J Clin Oncol. 2009 Apr 20;27(12):1999-2006. doi: 10.1200/JCO.2008.19.6618. Epub 2009 Mar 16.
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Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients.胃癌患者中ERBB2基因状态与组织病理学参数及疾病特异性生存的相关性
Br J Cancer. 2009 Feb 10;100(3):487-93. doi: 10.1038/sj.bjc.6604885. Epub 2009 Jan 20.
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Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer.胰岛素样生长因子1型受体、表皮生长因子受体和HER2表达对胃癌患者预后的影响。
Clin Cancer Res. 2008 May 15;14(10):3022-9. doi: 10.1158/1078-0432.CCR-07-1898.