血清脂肪细胞脂肪酸结合蛋白水平与中国女性冠心病严重程度相关。
Serum levels of adipocyte fatty acid-binding protein are associated with the severity of coronary artery disease in Chinese women.
机构信息
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital and Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai, China.
出版信息
PLoS One. 2011 Apr 28;6(4):e19115. doi: 10.1371/journal.pone.0019115.
BACKGROUND
Adipocyte fatty acid-binding protein (A-FABP) has been described as a novel adipokine, playing an important role in the development of metabolic syndrome, type 2 diabetes and atherosclerosis. In this study, we investigated the relationship between serum levels of A-FABP and the presence and severity of coronary artery disease (CAD) in Chinese subjects.
METHODOLOGY/PRINCIPAL FINDINGS: Circulating A-FABP level was determined by ELISA in 341 Chinese subjects (221 men, 120 women) who underwent coronary angiography. A-FABP levels in patients with CAD were significantly higher compared with non-CAD subjects (P = 0.029 in men; P = 0.031 in women). Serum A-FABP increased significantly in multi-vessel diseased patients than in non-CAD subjects (P = 0.011 in men, P = 0.004 in women), and showed an independent correlation with coronary atherosclerosis index (standardized β = 0.173, P = 0.025). In multiple logistic regression analysis, serum A-FABP was an independent risk factor for CAD in women (OR = 5.637, 95%CI: 1.299-24.457, P = 0.021). In addition, amino terminal pro-brain natriuretic peptide (NT-proBNP) was demonstrated to be positively and independently correlated with A-FABP (standardized β = 0.135, P = 0.027).
CONCLUSIONS/SIGNIFICANCE: Serum A-FABP is closely associated with the presence and severity of CAD in Chinese women.
背景
脂肪细胞脂肪酸结合蛋白（A-FABP）已被描述为一种新型脂肪因子，在代谢综合征、2 型糖尿病和动脉粥样硬化的发展中发挥重要作用。在这项研究中，我们研究了中国人血清 A-FABP 水平与冠状动脉疾病（CAD）的存在和严重程度之间的关系。
方法/主要发现：通过 ELISA 法测定 341 例接受冠状动脉造影的中国患者（221 例男性，120 例女性）的循环 A-FABP 水平。CAD 患者的 A-FABP 水平明显高于非 CAD 患者（男性 P = 0.029；女性 P = 0.031）。与非 CAD 患者相比，多支病变患者的血清 A-FABP 水平显著升高（男性 P = 0.011，女性 P = 0.004），并与冠状动脉粥样硬化指数呈独立相关（标准化β=0.173，P = 0.025）。在多因素 logistic 回归分析中，血清 A-FABP 是女性 CAD 的独立危险因素（OR = 5.637，95%CI：1.299-24.457，P = 0.021）。此外，氨基末端脑钠肽前体（NT-proBNP）与 A-FABP 呈正相关且独立相关（标准化β=0.135，P = 0.027）。
结论/意义：血清 A-FABP 与中国女性 CAD 的存在和严重程度密切相关。
Zotero 插件