Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan.
School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
Int J Environ Res Public Health. 2022 Aug 2;19(15):9459. doi: 10.3390/ijerph19159459.
The adipocyte fatty-acid binding protein (A-FABP) is predominantly expressed in macrophages and adipocytes and is an essential mediator of inflammation and atherosclerosis pathogenesis. Atherosclerosis is an aggravating factor for peripheral arterial disease (PAD). Our study intended to study the association between PAD and serum A-FABP levels in type-2 diabetes mellitus (T2DM) patients. One hundred and twenty T2DM subjects were enrolled in the study. Fasting blood samples were collected to determine biochemical data and A-FABP levels. By the automatic oscillometric method, the ankle−brachial index (ABI) was measured. Low ABI was defined as any value < 0.9. Twenty participants with T2DM (16.7%) were included in the low ABI group. Low ABI T2DM participants had an increased mean body mass index, body fat mass, systolic blood pressure, C-reactive protein, urine albumin−creatinine ratio, and A-FABP levels compared to those in the normal ABI group. After variables significantly associated with PAD were adjusted by multivariate logistic regression analyses, circulating A-FABP levels (odds ratio [OR]: 1.138; 95 percent confidence interval [CI]: 1.023−1.266; p = 0.017) were identified as the independent marker of PAD. In conclusion, fasting serum A-FABP value has positive association with PAD in T2DM patients.
脂肪细胞脂肪酸结合蛋白（A-FABP）主要在巨噬细胞和脂肪细胞中表达，是炎症和动脉粥样硬化发病机制的重要介质。动脉粥样硬化是外周动脉疾病（PAD）的加重因素。我们的研究旨在研究 2 型糖尿病（T2DM）患者中 PAD 与血清 A-FABP 水平之间的关系。本研究纳入了 120 名 T2DM 患者。采集空腹血样以确定生化数据和 A-FABP 水平。采用自动振荡法测量踝肱指数（ABI）。ABI 降低定义为任何<0.9 的值。20 名 T2DM 患者（16.7%）被纳入 ABI 降低组。与 ABI 正常组相比，ABI 降低的 T2DM 患者的平均体重指数、体脂肪量、收缩压、C 反应蛋白、尿白蛋白/肌酐比值和 A-FABP 水平均升高。多元逻辑回归分析调整与 PAD 显著相关的变量后，循环 A-FABP 水平（比值比 [OR]：1.138；95%置信区间 [CI]：1.023-1.266；p = 0.017）被确定为 PAD 的独立标志物。总之，空腹血清 A-FABP 值与 T2DM 患者的 PAD 呈正相关。
