Bacchetti S, Counter C
Int J Oncol. 1995 Sep;7(3):423-32.
Telomerase has recently come into the limelight as one of the most prevalent tumour markers, due to its nearly ubiquitous presence in malignant tissues and absence from most somatic tissues. The essential role of telomeres in unlimited cell proliferation and that of the enzyme in telomere maintenance have suggested that telomerase inhibitors may be effective in cancer therapy. We provide here a compendium and an evaluation of the available data relating to this hypothesis.
由于端粒酶在恶性组织中几乎普遍存在，而在大多数体细胞组织中不存在，它最近作为最普遍的肿瘤标志物之一而备受关注。端粒在细胞无限增殖中的重要作用以及该酶在端粒维持中的作用表明，端粒酶抑制剂可能在癌症治疗中有效。我们在此提供了与该假说相关的现有数据的综述和评估。
