Rajavel Malligarjunan, Mullins Michael R, Taylor Derek J
Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland OH 44106, USA.
Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland OH 44106, USA; Department of Biochemistry, Case Western Reserve University, School of Medicine, Cleveland OH 44106, USA.
Biochim Biophys Acta. 2014 Sep;1844(9):1550-9. doi: 10.1016/j.bbapap.2014.04.014. Epub 2014 Apr 26.
Telomeres are nucleoprotein complexes that cap the ends of all linear chromosomes and function to prevent aberrant repair and end-to-end chromosome fusions. In somatic cells, telomere shortening is a natural part of the aging process as it occurs with each round of cell division. In germ and stem cells, however, the enzyme telomerase synthesizes telomere DNA to counter-balance telomere shortening and help maintain cellular proliferation. Of the primary telomere end-binding proteins, TPP1 has recently emerged as a primary contributor in protecting telomere DNA and in recruiting telomerase to the telomere ends. In this review, we summarize the current knowledge regarding the role of TPP1 in telomere maintenance.
端粒是一种核蛋白复合体，它覆盖所有线性染色体的末端，其功能是防止异常修复和染色体端对端融合。在体细胞中，端粒缩短是衰老过程的自然组成部分，因为它会随着每一轮细胞分裂而发生。然而，在生殖细胞和干细胞中，端粒酶会合成端粒DNA，以抵消端粒缩短并帮助维持细胞增殖。在主要的端粒末端结合蛋白中，TPP1最近已成为保护端粒DNA以及将端粒酶招募到端粒末端的主要贡献者。在这篇综述中，我们总结了目前关于TPP1在端粒维持中作用的知识。
