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非典型性成神经管细胞瘤。

Atypical adult medulloblastoma.

机构信息

Department of Neurosurgery, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK.

出版信息

Acta Neurochir (Wien). 2011 Jul;153(7):1511-7; discussion 1517. doi: 10.1007/s00701-011-1040-3. Epub 2011 May 9.

Abstract

Medulloblastomas are malignant primitive neuro-ectodermal neoplasms of childhood. In adults, clinical manifestations, imaging and prognosis can be different from that observed in children. Three adult patients with confirmed diagnoses of medulloblastoma are discussed in this report. They presented with unusually prolonged clinical courses and with imaging more suggestive of L'hermitte-Duclos disease. Medulloblastoma should be considered in all adults with posterior fossa masses despite having clinical and radiological features suggestive of a low-grade tumour. Definitive diagnosis requires histological confirmation in all cases.

摘要

成神经管细胞瘤是儿童期恶性原始神经外胚层肿瘤。在成年人中,临床表现、影像学表现和预后可能与儿童观察到的不同。本文报道了 3 例经证实的成神经管细胞瘤成人患者。他们表现出异常延长的临床病程,影像学表现更提示为 L'hermitte-Duclos 病。尽管临床表现和影像学特征提示为低级别肿瘤,所有后颅窝肿块的成年患者均应考虑成神经管细胞瘤。所有病例均需组织学证实明确诊断。

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