Meshkini Ali, Vahedi Amir, Meshkini Mohammad, Alikhah Hossein, Naghavi-Behzad Mohammad
Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran.
Asian J Neurosurg. 2014 Jan;9(1):45-7. doi: 10.4103/1793-5482.131077.
Medulloblastoma is common in children as a tumor of midline posterior fossa, which arises from vermis and appears as a homogenously enhancing hyperdense mass on computed tomography scan and is associated with the clinical picture of posterior fossa syndrome. This unique clinic-radiological pattern in considered "typical" medulloblastoma, but medulloblastomas does not follow the typical clinic-radiological pattern in a significant number of children and adult cases. We review here the previous reports of atypical or uncommon features of medulloblastoma and add our very rare atypical cases of medulloblastomas to this list. Medulloblastoma should be considered in all midline posterior fossa tumors, hemisphere and cerebellopontine angle despite having clinical and radiological features suggestive of other tumors. Definitive diagnosis requires histologic confirmation in all cases.
髓母细胞瘤在儿童中较为常见,是一种位于后颅窝中线的肿瘤,起源于小脑蚓部,在计算机断层扫描上表现为均匀强化的高密度肿块,并伴有后颅窝综合征的临床表现。这种独特的临床-放射学模式被认为是“典型”髓母细胞瘤,但在相当数量的儿童和成人病例中,髓母细胞瘤并不遵循典型的临床-放射学模式。我们在此回顾先前关于髓母细胞瘤非典型或罕见特征的报道,并将我们非常罕见的髓母细胞瘤非典型病例加入此列表。尽管具有提示其他肿瘤的临床和放射学特征,但所有位于后颅窝中线、半球及桥小脑角的肿瘤均应考虑髓母细胞瘤的可能。所有病例的明确诊断均需组织学证实。