Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, Boston, MA 02118, USA.
Skeletal Radiol. 2011 Aug;40(8):1017-23. doi: 10.1007/s00256-011-1097-3. Epub 2011 May 8.
Intrasubstance meniscal signal changes not reaching the articular surface on fast spin echo (FSE) sequences are considered to represent mucoid degeneration on MRI. The aim of this study was to evaluate the association of prevalent intrasubstance signal changes with incident tears of the medial meniscus detected on 3.0 T MRI over a 1-year period.
A total of 161 women aged ≥ 40 years participated in a longitudinal 1-year observational study of knee osteoarthritis. MRI (3.0 T) was performed at baseline and 12-month follow-up. The anterior horn, body, and posterior horn of the medial meniscus were scored by two experienced musculoskeletal radiologists using the Boston-Leeds Osteoarthritis Knee Score (BLOKS) system. Four grades were used to describe the meniscal morphology: grade 0 (normal), grade 1 (intrasubstance signal changes not reaching the articular surface), grade 2 (single tears), and grade 3 (complex tears and maceration). Fisher's exact test and the Cochran-Armitage trend test were performed to evaluate whether baseline intrasubstance signal changes (grade 1) predict incident meniscal tears/maceration (grades 2 and/or 3) in the same subregion of the medial meniscus, when compared to subregions without pathology as the reference group (grade 0).
Medial meniscal intrasubstance signal changes at baseline did not predict tears at follow-up when evaluating the anterior and posterior horns (left-sided p-values 0.06 and 0.59, respectively). No incident tears were detected in the body.
We could not demonstrate an association between prevalent medial meniscal intrasubstance signal changes with incident tears over a 1-year period.
在快速自旋回波（FSE）序列上，未到达关节面的半月板内信号改变被认为代表 MRI 上的黏液样变性。本研究旨在评估在 3.0T MRI 上，在 1 年内发现内侧半月板内信号改变与内侧半月板撕裂的相关性。
共有 161 名年龄≥40 岁的女性参与了一项膝关节骨关节炎的 1 年纵向观察研究。在基线和 12 个月的随访时进行 MRI（3.0T）检查。两位有经验的肌肉骨骼放射科医生使用波士顿-利兹骨关节炎膝关节评分（BLOKS）系统对内侧半月板的前角、体部和后角进行评分。采用 4 级评分描述半月板形态：0 级（正常）、1 级（半月板内信号改变未达关节面）、2 级（单个撕裂）和 3 级（复杂撕裂和糜烂）。采用 Fisher 确切检验和 Cochran-Armitage 趋势检验评估基线内侧半月板内信号改变（1 级）是否预测同一内侧半月板区域的半月板撕裂/糜烂（2 级和/或 3 级），并将无病变的亚区作为参考组（0 级）。
当评估内侧半月板的前角和后角时，基线时的内侧半月板内信号改变并未预测随访时的撕裂（左侧的 P 值分别为 0.06 和 0.59）。在体部未发现新的撕裂。
我们无法证明在 1 年内，内侧半月板内信号改变与撕裂之间存在相关性。
