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[Prevalence of vitamin B-12 deficiency in older adults].[老年人维生素B-12缺乏症的患病率]
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Peripheral neuropathy: differential diagnosis and management.周围神经病:鉴别诊断与治疗。
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High frequency of low serum levels of vitamin 12 among patients attending Jordan University Hospital.在约旦大学医院就诊的患者中,维生素 12 血清水平低的频率较高。
East Mediterr Health J. 2009 Jul-Aug;15(4):853-60.
5
Cervical myelopathy: a clinical and radiographic evaluation and correlation to cervical spondylotic myelopathy.脊髓型颈椎病:临床及影像学评估及其与脊髓型颈椎病的相关性
Spine (Phila Pa 1976). 2010 Mar 15;35(6):620-4. doi: 10.1097/BRS.0b013e3181b723af.
6
Computed tomography-evaluated features of spinal degeneration: prevalence, intercorrelation, and association with self-reported low back pain.计算机断层扫描评估的脊柱退变特征:患病率、相关性以及与自我报告的下腰痛的关系。
Spine J. 2010 Mar;10(3):200-8. doi: 10.1016/j.spinee.2009.10.018. Epub 2009 Dec 16.
7
Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy.并非所有糖尿病性神经病都是糖尿病引起的:糖尿病性神经病的鉴别诊断。
Curr Diab Rep. 2009 Dec;9(6):423-31. doi: 10.1007/s11892-009-0069-7.
8
Spinal stenosis prevalence and association with symptoms: the Framingham Study.脊柱狭窄的患病率及其与症状的关联:弗雷明汉研究
Spine J. 2009 Jul;9(7):545-50. doi: 10.1016/j.spinee.2009.03.005. Epub 2009 Apr 23.
9
The multi-faceted basis of vitamin B12 (cobalamin) neurotrophism in adult central nervous system: Lessons learned from its deficiency.成人中枢神经系统中维生素B12(钴胺素)神经营养作用的多方面基础:从其缺乏症中吸取的教训
Prog Neurobiol. 2009 Jul;88(3):203-20. doi: 10.1016/j.pneurobio.2009.04.004. Epub 2009 Apr 24.
10
B vitamins alleviate indices of neuropathic pain in diabetic rats.B族维生素可减轻糖尿病大鼠的神经性疼痛指标。
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因脊柱狭窄和维生素 B12 缺乏导致的双重病理。

Dual pathology as a result of spinal stenosis and vitamin B12 deficiency.

机构信息

Orthopaedic Department, Leicester General Hospital, Gwendelon Road, Leicester LE5 4PW, UK.

出版信息

Eur Spine J. 2011 Dec;20(12):2247-51. doi: 10.1007/s00586-011-1834-2. Epub 2011 May 8.

DOI:10.1007/s00586-011-1834-2
PMID:21553339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3229725/
Abstract

Vitamin B12 deficiency can confound the clinical assessment of patients presenting with features of spinal disorders. Speciality practice within spinal surgery may lead the clinician to a focus upon spinal explanations for symptoms and that belief may be reinforced by supporting imaging. In the presence of mainly sensory symptoms consideration and exclusion of non surgical causes needs to occur. This study aimed at identifying the prevalence of vitamin B12 deficiency; the presence of dual pathology on imaging performed; the implementation of replacement therapy and their subsequent clinical response as perceived by patients. This was performed through a retrospective review of patients presenting to specialist spine out-patient clinics over a 4-year period via access to pathology reports followed by a telephone survey. 457 patients were investigated of which 8.5% were vitamin B12 deficient. 70% of patients had repeat levels and 31% continued to be deficient. 26% of these patients were not placed on any supplemental therapy. 72% of patients on treatment had self perceived improved outcomes as compared with 55% not on treatment. 73% of patients underwent MRI/CT imaging. 59% of which had evidence of spinal stenosis. In older patients with sensory symptoms, the coexistence of B12 deficiency should be considered. Detection of deficiency with consequent treatment results in better global outcomes than no treatment. Unless the correct blood test is done, the pathology will remain undetected, and patients may continue with their primary symptoms despite high-risk spinal surgical procedures.

摘要

维生素 B12 缺乏症可能会使出现脊柱疾病特征的患者的临床评估变得复杂。脊柱外科的专业实践可能会使临床医生专注于脊柱对症状的解释,而影像学的支持可能会加强这种信念。在主要表现为感觉症状的情况下,需要考虑并排除非手术原因。本研究旨在确定维生素 B12 缺乏症的患病率;影像学检查中双重病变的存在;替代治疗的实施及其随后被患者感知到的临床反应。这是通过回顾性分析在 4 年期间通过访问病理报告向专科脊柱门诊就诊的患者来完成的,随后进行了电话调查。共调查了 457 名患者,其中 8.5%的患者存在维生素 B12 缺乏症。70%的患者进行了重复检测,其中 31%仍然缺乏维生素 B12。这些患者中有 26%没有接受任何补充治疗。接受治疗的患者中有 72%自我感觉治疗效果更好,而未接受治疗的患者只有 55%。接受治疗的患者中有 73%进行了 MRI/CT 影像学检查。其中 59%有脊柱狭窄的证据。对于有感觉症状的老年患者,应考虑存在 B12 缺乏症。发现缺乏症并进行相应的治疗可带来更好的整体效果,而不进行治疗则效果不佳。除非进行了正确的血液检查,否则病理将无法被发现,患者可能会继续出现主要症状,尽管他们已经接受了高风险的脊柱手术。