Orthopaedic Department, Leicester General Hospital, Gwendelon Road, Leicester LE5 4PW, UK.
Eur Spine J. 2011 Dec;20(12):2247-51. doi: 10.1007/s00586-011-1834-2. Epub 2011 May 8.
Vitamin B12 deficiency can confound the clinical assessment of patients presenting with features of spinal disorders. Speciality practice within spinal surgery may lead the clinician to a focus upon spinal explanations for symptoms and that belief may be reinforced by supporting imaging. In the presence of mainly sensory symptoms consideration and exclusion of non surgical causes needs to occur. This study aimed at identifying the prevalence of vitamin B12 deficiency; the presence of dual pathology on imaging performed; the implementation of replacement therapy and their subsequent clinical response as perceived by patients. This was performed through a retrospective review of patients presenting to specialist spine out-patient clinics over a 4-year period via access to pathology reports followed by a telephone survey. 457 patients were investigated of which 8.5% were vitamin B12 deficient. 70% of patients had repeat levels and 31% continued to be deficient. 26% of these patients were not placed on any supplemental therapy. 72% of patients on treatment had self perceived improved outcomes as compared with 55% not on treatment. 73% of patients underwent MRI/CT imaging. 59% of which had evidence of spinal stenosis. In older patients with sensory symptoms, the coexistence of B12 deficiency should be considered. Detection of deficiency with consequent treatment results in better global outcomes than no treatment. Unless the correct blood test is done, the pathology will remain undetected, and patients may continue with their primary symptoms despite high-risk spinal surgical procedures.
维生素 B12 缺乏症可能会使出现脊柱疾病特征的患者的临床评估变得复杂。脊柱外科的专业实践可能会使临床医生专注于脊柱对症状的解释,而影像学的支持可能会加强这种信念。在主要表现为感觉症状的情况下,需要考虑并排除非手术原因。本研究旨在确定维生素 B12 缺乏症的患病率;影像学检查中双重病变的存在;替代治疗的实施及其随后被患者感知到的临床反应。这是通过回顾性分析在 4 年期间通过访问病理报告向专科脊柱门诊就诊的患者来完成的,随后进行了电话调查。共调查了 457 名患者,其中 8.5%的患者存在维生素 B12 缺乏症。70%的患者进行了重复检测,其中 31%仍然缺乏维生素 B12。这些患者中有 26%没有接受任何补充治疗。接受治疗的患者中有 72%自我感觉治疗效果更好,而未接受治疗的患者只有 55%。接受治疗的患者中有 73%进行了 MRI/CT 影像学检查。其中 59%有脊柱狭窄的证据。对于有感觉症状的老年患者,应考虑存在 B12 缺乏症。发现缺乏症并进行相应的治疗可带来更好的整体效果,而不进行治疗则效果不佳。除非进行了正确的血液检查,否则病理将无法被发现,患者可能会继续出现主要症状,尽管他们已经接受了高风险的脊柱手术。