Gu J J, Rafalson L, Zhao G M, Wu H Y, Zhou Y, Jiang Q W, Bai Y, Zhu Q L, Fu X J, Zhang H, Qiu H, Yang L M, Ruan X N, Xu W H
Health Bureau of Shanghai Pudong New Area, PRC.
Exp Clin Endocrinol Diabetes. 2011 Jul;119(7):387-94. doi: 10.1055/s-0031-1277141. Epub 2011 May 6.
Numerous studies have demonstrated the ability of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) to predict the risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). This study aimed to evaluate the predictive value of these anthropometries for metabolic abnormalities and related diseases in Chinese adults.
MATERIAL & METHODS: A cross-sectional study was conducted in 2 477 men and 3 107 women at 20-79 years old who were randomly selected from Pudong New Area of Shanghai, China, through a multistage sampling process. Anthropometric variables and blood pressure were measured according to a standardized protocol, and a fasting blood sample was collected from each subject for biochemical analysis.
Prevalence of the metabolic syndrome was observed to increase with increasing BMI, WC, WHR and WHtR in both sexes. Participants with any metabolic abnormality had a higher body size than those without. The associations of anthropometries with each metabolic factor were significant and equal for BMI, WC, WHR and WHtR. Areas under the receiver operating characteristic curves (AUC) ranged from 0.59 to 0.72 across the 4 anthropometries in predicting individual and clusters of metabolic factors. However, none of the 4 anthropometries identified newly-diagnosed T2DM or hypertension with a high sensitivity or specificity.
Our findings suggest that the independent use of BMI, WC, WHR, or WHtR may not be an effective tool to predict metabolic factors and related chronic diseases in Chinese adults.
大量研究已证明体重指数（BMI）、腰围（WC）、腰臀比（WHR）和腰高比（WHtR）能够预测2型糖尿病（T2DM）和心血管疾病（CVD）的风险。本研究旨在评估这些人体测量指标对中国成年人代谢异常及相关疾病的预测价值。
通过多阶段抽样程序，对从中国上海浦东新区随机选取的2477名20至79岁男性和3107名20至79岁女性进行了横断面研究。根据标准化方案测量人体测量变量和血压，并采集每位受试者的空腹血样进行生化分析。
观察到代谢综合征的患病率在男女两性中均随BMI、WC、WHR和WHtR的增加而升高。有任何代谢异常的参与者的体型均大于无代谢异常者。BMI、WC、WHR和WHtR与各代谢因素的关联均显著且相当。在预测单个代谢因素和代谢因素集群时，4种人体测量指标的受试者工作特征曲线下面积（AUC）范围为0.59至0.72。然而，这4种人体测量指标均未以高灵敏度或高特异性识别新诊断的T2DM或高血压。
我们的研究结果表明，单独使用BMI、WC、WHR或WHtR可能不是预测中国成年人代谢因素及相关慢性病的有效工具。
