Citak Necati, Sayar Adnan, Metin Muzaffer, Pekçolaklar Atilla, Kök Abdulaziz, Akanıl Fener Neslihan, Celikten Alper, Gürses Atilla
Clinic of 1st Chest Surgery, Yedikule Chest Diseases and Chest Surgery, Training and Research Hospital, Istanbul, Turkey.
Tuberk Toraks. 2011;59(1):62-9. doi: 10.5578/tt.1755.
Surgery for pulmonary aspergilloma is reputed to be risky. We analyzed our results of the surgical treatment for pulmonary aspergilloma. Between 2003 and 2009, 26 patients underwent thoracotomy for treatment of pulmonary aspergilloma in our center. Results were evaluated retrospectively. There were 5 female and 21 male patients, with a mean age of 44 ± 11.6 years (28-70). The patients were divided into two groups, group A (simple aspergilloma; n= 8) and group B (complex aspergilloma; n= 18). Major underlying diseases were tuberculosis (61.5%). The most common indication for operation was hemoptysis (57.6%). Of our patients, 23% were complaining of massive hemoptysis or recurrent hemoptysis. Other patients were complaining of mild symptoms and some of them were totally asymptomatic. We performed 15 (57.6%) lobectomies (3 with associated segmentectomies), 8 (30.6%) segmentectomies/wedge resections, 2 (7.6%) pneumonectomies, and 1 (3.8%) cavernoplasty. Postoperative complications occurred in 15 (57.6%) patients. Complications occurred in 72.2% patients of complex aspergilloma, whereas 25% occurred in simple aspergilloma (p= 0.03). Major complications included prolonged air leak, empyema, air space. One patient who underwent lobectomies for complex aspergilloma developed bronchopleural fistula and died of respiratory failure on the 20th postoperative day. Operative mortality was 3.8%. The average postoperative hospital stay was 12.9 days. The mean follow-up period was average 44 months. The actuarial survival at 3 years was 90% and 100% for complex aspergilloma and simple aspergilloma, respectively (p> 0.05). There was two recurrence of disease (8%). But no recurrence of hemoptysis. Low morbidity rate may have been due to the selection of patients with localized pulmonary disease in this study. Surgical resection of asymptomatic or symptomatic pulmonary aspergilloma is effective in preventing recurrence or massive hemoptysis for patients whose condition is fit for pulmonary resection with reasonable mortality, morbidity and survival rates.
肺曲菌球手术被认为具有风险。我们分析了我们中心肺曲菌球手术治疗的结果。2003年至2009年期间,26例患者在我们中心接受了开胸手术治疗肺曲菌球。对结果进行回顾性评估。有5名女性和21名男性患者,平均年龄为44±11.6岁(28 - 70岁)。患者分为两组,A组(单纯曲菌球;n = 8)和B组(复杂曲菌球;n = 18)。主要基础疾病为肺结核(61.5%)。最常见的手术指征是咯血(57.6%)。我们的患者中,23%主诉大量咯血或反复咯血。其他患者主诉症状较轻,其中一些完全无症状。我们进行了15例(57.6%)肺叶切除术(3例伴有相关段切除术)、8例(30.6%)段切除术/楔形切除术、2例(7.6%)全肺切除术和1例(3.8%)空洞成形术。15例(57.6%)患者发生术后并发症。复杂曲菌球患者中72.2%发生并发症,而单纯曲菌球患者中25%发生并发症(p = 0.03)。主要并发症包括持续漏气、脓胸、气腔。1例因复杂曲菌球接受肺叶切除术的患者发生支气管胸膜瘘,术后第20天死于呼吸衰竭。手术死亡率为3.8%。术后平均住院时间为12.9天。平均随访期为44个月。复杂曲菌球和单纯曲菌球3年的精算生存率分别为90%和100%(p>0.05)。有2例疾病复发(8%)。但无咯血复发。低发病率可能归因于本研究中对局限性肺部疾病患者的选择。对于适合肺切除且死亡率、发病率和生存率合理的患者,手术切除无症状或有症状的肺曲菌球在预防复发或大量咯血方面是有效的。