Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, Japan.
FEBS J. 2011 Sep;278(18):3190-203. doi: 10.1111/j.1742-4658.2011.08170.x. Epub 2011 Jun 13.
The ATP-binding cassette protein A1 (ABCA1) mediates the secretion of cellular-free cholesterol and phospholipids to an extracellular acceptor, apolipoprotein A-I, to form high-density lipoprotein. Because ABCA1 is a key factor in cholesterol homeostasis, elaborate transcriptional and post-transcriptional regulations of ABCA1 have evolved to maintain cholesterol homeostasis. Recent studies suggest that ABCA1 moves lipids not only between membranes but also within membranes to organize and reorganize membrane meso-domains to modulate cell proliferation and immunity.
三磷酸腺苷结合盒蛋白 A1（ABCA1）介导细胞内游离胆固醇和磷脂向细胞外受体载脂蛋白 A-I 的分泌，形成高密度脂蛋白。由于 ABCA1 是胆固醇稳态的关键因素，因此 ABCA1 的转录和转录后调控已经进化到精细的程度，以维持胆固醇稳态。最近的研究表明，ABCA1 不仅在膜间移动脂质，而且在膜内移动脂质，以组织和重组膜介域，从而调节细胞增殖和免疫。
