Wu Kun, Zou Longwei, Lei Xiaoyong, Yang Xiaoyan
School of Pharmacy, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
The Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang, Hunan 421001, P.R. China.
Oncol Lett. 2022 Aug 19;24(4):349. doi: 10.3892/ol.2022.13469. eCollection 2022 Oct.
Studies have indicated that anticancer drugs targeting cholesterol metabolism have clinical significance. From the perspective of the mechanism of cholesterol excretion from cells, ATP-binding cassette (ABC)A1 has an essential role that cannot be ignored. ABCA1 is located on the cell membrane and able to mediate the efflux of lipids, such as intracellular cholesterol, thereby initiating reverse cholesterol transport to reduce the intracellular cholesterol level. Therefore, inducing the expression of ABCA1 may become a new breakthrough point in cancer therapy.
研究表明，靶向胆固醇代谢的抗癌药物具有临床意义。从细胞内胆固醇排泄机制的角度来看，ATP结合盒转运体A1（ABCA1）具有不可忽视的重要作用。ABCA1位于细胞膜上，能够介导细胞内胆固醇等脂质的外流，从而启动胆固醇逆向转运以降低细胞内胆固醇水平。因此，诱导ABCA1的表达可能成为癌症治疗的新突破点。
